Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen
Identifieur interne : 006415 ( Main/Exploration ); précédent : 006414; suivant : 006416Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen
Auteurs : N. Gagliani [Italie] ; T. Jofra [Italie] ; A. Valle [Italie] ; A. Stabilini [Italie] ; C. Morsiani [Italie] ; S. Gregori [Italie] ; S. Deng [États-Unis] ; D. M. Rothstein [États-Unis] ; M. Atkinson [États-Unis] ; M. Kamanaka [États-Unis] ; R. A. Flavell [États-Unis] ; M. G. Roncarolo [Italie] ; M. Battaglia [Italie]Source :
- American journal of transplantation : (Print) [ 1600-6135 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Chirurgie.
English descriptors
- KwdEn :
Abstract
The immune system is comprised of several CD4+ T regulatory (Treg) cell types, of which two, the Foxp3+ Treg and T regulatory type 1 (Tr1) cells, have frequently been associated with transplant tolerance. However, whether and how these two Treg-cell types synergize to promote allograft tolerance remains unknown. We previously developed a mouse model of allogeneic transplantation in which a specific immunomodulatory treatment leads to transplant tolerance through both Foxp3+ Treg and Tr1 cells. Here, we show that Foxp3+ Treg cells exert their regulatory function within the allograft and initiate engraftment locally and in a non-antigen (Ag) specific manner. Whereas CD4+CD25- T cells, which contain Tr1 cells, act from the spleen and are key to the maintenance of long-term tolerance. Importantly, the role of Foxp3+ Treg and Tr1 cells is not redundant once they are simultaneously expanded/induced in the same host. Moreover, our data show that long-term tolerance induced by Foxp3+ Treg-cell transfer is sustained by splenic Tr1 cells and functionally moves from the allograft to the spleen.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001B73
- to stream PascalFrancis, to step Curation: 002D94
- to stream PascalFrancis, to step Checkpoint: 000F49
- to stream Main, to step Merge: 006770
- to stream Main, to step Curation: 006415
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen</title><author><name sortKey="Gagliani, N" sort="Gagliani, N" uniqKey="Gagliani N" first="N." last="Gagliani">N. Gagliani</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Telethon Institute for Gene Therapy</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Vita-Salute San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Jofra, T" sort="Jofra, T" uniqKey="Jofra T" first="T." last="Jofra">T. Jofra</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Valle, A" sort="Valle, A" uniqKey="Valle A" first="A." last="Valle">A. Valle</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Stabilini, A" sort="Stabilini, A" uniqKey="Stabilini A" first="A." last="Stabilini">A. Stabilini</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Morsiani, C" sort="Morsiani, C" uniqKey="Morsiani C" first="C." last="Morsiani">C. Morsiani</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gregori, S" sort="Gregori, S" uniqKey="Gregori S" first="S." last="Gregori">S. Gregori</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Telethon Institute for Gene Therapy</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Deng, S" sort="Deng, S" uniqKey="Deng S" first="S." last="Deng">S. Deng</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medicine, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation></author><author><name sortKey="Rothstein, D M" sort="Rothstein, D M" uniqKey="Rothstein D" first="D. M." last="Rothstein">D. M. Rothstein</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Starzl Transplantation Institute, University of Pittsburgh Medical Center</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Atkinson, M" sort="Atkinson, M" uniqKey="Atkinson M" first="M." last="Atkinson">M. Atkinson</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Pathology, The University of Florida</s1><s2>Gainesville, FL</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Gainesville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Kamanaka, M" sort="Kamanaka, M" uniqKey="Kamanaka M" first="M." last="Kamanaka">M. Kamanaka</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Immunobiology, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation></author><author><name sortKey="Flavell, R A" sort="Flavell, R A" uniqKey="Flavell R" first="R. A." last="Flavell">R. A. Flavell</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Immunobiology, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Howard Hughes Medical Institute</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Howard Hughes Medical Institute</wicri:noRegion></affiliation></author><author><name sortKey="Roncarolo, M G" sort="Roncarolo, M G" uniqKey="Roncarolo M" first="M. G." last="Roncarolo">M. G. Roncarolo</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Telethon Institute for Gene Therapy</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Vita-Salute San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Battaglia, M" sort="Battaglia, M" uniqKey="Battaglia M" first="M." last="Battaglia">M. Battaglia</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0285793</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0285793 INIST</idno><idno type="RBID">Pascal:13-0285793</idno><idno type="wicri:Area/PascalFrancis/Corpus">001B73</idno><idno type="wicri:Area/PascalFrancis/Curation">002D94</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F49</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000F49</idno><idno type="wicri:doubleKey">1600-6135:2013:Gagliani N:transplant:tolerance:to</idno><idno type="wicri:Area/Main/Merge">006770</idno><idno type="wicri:Area/Main/Curation">006415</idno><idno type="wicri:Area/Main/Exploration">006415</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen</title><author><name sortKey="Gagliani, N" sort="Gagliani, N" uniqKey="Gagliani N" first="N." last="Gagliani">N. Gagliani</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Telethon Institute for Gene Therapy</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Vita-Salute San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Jofra, T" sort="Jofra, T" uniqKey="Jofra T" first="T." last="Jofra">T. Jofra</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Valle, A" sort="Valle, A" uniqKey="Valle A" first="A." last="Valle">A. Valle</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Stabilini, A" sort="Stabilini, A" uniqKey="Stabilini A" first="A." last="Stabilini">A. Stabilini</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Morsiani, C" sort="Morsiani, C" uniqKey="Morsiani C" first="C." last="Morsiani">C. Morsiani</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gregori, S" sort="Gregori, S" uniqKey="Gregori S" first="S." last="Gregori">S. Gregori</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Telethon Institute for Gene Therapy</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Deng, S" sort="Deng, S" uniqKey="Deng S" first="S." last="Deng">S. Deng</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medicine, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation></author><author><name sortKey="Rothstein, D M" sort="Rothstein, D M" uniqKey="Rothstein D" first="D. M." last="Rothstein">D. M. Rothstein</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Starzl Transplantation Institute, University of Pittsburgh Medical Center</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Atkinson, M" sort="Atkinson, M" uniqKey="Atkinson M" first="M." last="Atkinson">M. Atkinson</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Pathology, The University of Florida</s1><s2>Gainesville, FL</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Gainesville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Kamanaka, M" sort="Kamanaka, M" uniqKey="Kamanaka M" first="M." last="Kamanaka">M. Kamanaka</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Immunobiology, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation></author><author><name sortKey="Flavell, R A" sort="Flavell, R A" uniqKey="Flavell R" first="R. A." last="Flavell">R. A. Flavell</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Immunobiology, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Howard Hughes Medical Institute</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Howard Hughes Medical Institute</wicri:noRegion></affiliation></author><author><name sortKey="Roncarolo, M G" sort="Roncarolo, M G" uniqKey="Roncarolo M" first="M. G." last="Roncarolo">M. G. Roncarolo</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Telethon Institute for Gene Therapy</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Vita-Salute San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Battaglia, M" sort="Battaglia, M" uniqKey="Battaglia M" first="M." last="Battaglia">M. Battaglia</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>San Raffaele Scientific Institute, Diabetes Research Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">American journal of transplantation : (Print)</title><title level="j" type="abbreviated">Am. j. transplant. : (Print)</title><idno type="ISSN">1600-6135</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of transplantation : (Print)</title><title level="j" type="abbreviated">Am. j. transplant. : (Print)</title><idno type="ISSN">1600-6135</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Graft</term><term>Immune tolerance</term><term>Langerhans islet</term><term>Spleen</term><term>Surgery</term><term>T regulatory cell</term><term>Transplantation</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Greffe</term><term>Tolérance immune</term><term>Transplantation</term><term>Traitement</term><term>Ilot Langerhans</term><term>Rate</term><term>Chirurgie</term><term>Lymphocyte T régulateur</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The immune system is comprised of several CD4<sup>+</sup> T regulatory (Treg) cell types, of which two, the Foxp3<sup>+</sup> Treg and T regulatory type 1 (Tr1) cells, have frequently been associated with transplant tolerance. However, whether and how these two Treg-cell types synergize to promote allograft tolerance remains unknown. We previously developed a mouse model of allogeneic transplantation in which a specific immunomodulatory treatment leads to transplant tolerance through both Foxp3<sup>+</sup> Treg and Tr1 cells. Here, we show that Foxp3<sup>+</sup> Treg cells exert their regulatory function within the allograft and initiate engraftment locally and in a non-antigen (Ag) specific manner. Whereas CD4<sup>+</sup>CD25<sup>-</sup> T cells, which contain Tr1 cells, act from the spleen and are key to the maintenance of long-term tolerance. Importantly, the role of Foxp3<sup>+</sup> Treg and Tr1 cells is not redundant once they are simultaneously expanded/induced in the same host. Moreover, our data show that long-term tolerance induced by Foxp3<sup>+</sup> Treg-cell transfer is sustained by splenic Tr1 cells and functionally moves from the allograft to the spleen.</div></front></TEI><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Gagliani, N" sort="Gagliani, N" uniqKey="Gagliani N" first="N." last="Gagliani">N. Gagliani</name></region><name sortKey="Battaglia, M" sort="Battaglia, M" uniqKey="Battaglia M" first="M." last="Battaglia">M. Battaglia</name><name sortKey="Gagliani, N" sort="Gagliani, N" uniqKey="Gagliani N" first="N." last="Gagliani">N. Gagliani</name><name sortKey="Gagliani, N" sort="Gagliani, N" uniqKey="Gagliani N" first="N." last="Gagliani">N. Gagliani</name><name sortKey="Gregori, S" sort="Gregori, S" uniqKey="Gregori S" first="S." last="Gregori">S. Gregori</name><name sortKey="Jofra, T" sort="Jofra, T" uniqKey="Jofra T" first="T." last="Jofra">T. Jofra</name><name sortKey="Morsiani, C" sort="Morsiani, C" uniqKey="Morsiani C" first="C." last="Morsiani">C. Morsiani</name><name sortKey="Roncarolo, M G" sort="Roncarolo, M G" uniqKey="Roncarolo M" first="M. G." last="Roncarolo">M. G. Roncarolo</name><name sortKey="Roncarolo, M G" sort="Roncarolo, M G" uniqKey="Roncarolo M" first="M. G." last="Roncarolo">M. G. Roncarolo</name><name sortKey="Stabilini, A" sort="Stabilini, A" uniqKey="Stabilini A" first="A." last="Stabilini">A. Stabilini</name><name sortKey="Valle, A" sort="Valle, A" uniqKey="Valle A" first="A." last="Valle">A. Valle</name></country><country name="États-Unis"><noRegion><name sortKey="Deng, S" sort="Deng, S" uniqKey="Deng S" first="S." last="Deng">S. Deng</name></noRegion><name sortKey="Atkinson, M" sort="Atkinson, M" uniqKey="Atkinson M" first="M." last="Atkinson">M. Atkinson</name><name sortKey="Flavell, R A" sort="Flavell, R A" uniqKey="Flavell R" first="R. A." last="Flavell">R. A. Flavell</name><name sortKey="Flavell, R A" sort="Flavell, R A" uniqKey="Flavell R" first="R. A." last="Flavell">R. A. Flavell</name><name sortKey="Kamanaka, M" sort="Kamanaka, M" uniqKey="Kamanaka M" first="M." last="Kamanaka">M. Kamanaka</name><name sortKey="Rothstein, D M" sort="Rothstein, D M" uniqKey="Rothstein D" first="D. M." last="Rothstein">D. M. Rothstein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006415 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006415 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:13-0285793
|texte= Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen
}}
| This area was generated with Dilib version V0.6.38. |  |